Endocrine Abstracts

Introduction: Adrenal incidentalomas (AIs) are frequently detected due to the increasing use of abdominal imaging for diagnostic purposes. However, few prospective studies exist with respect to their natural history, regarding their size and clinical course. The aim of this study was to report the prevalence and natural history of AIs.Methods/design: Interim analysis of a prospective cohort study. The following tests were performed: serum cortisol noctur...

Introduction: Commonly used pre-operative methods (ultrasonography and sestamibi scan) to localize the culprit parathyroid gland(s) in patients with primary hyperparathyroidism (PHPT), frequently yield false positive or false negative results. Parathyroid hormone (PTH) washout after fine-needle aspiration (FNA) may allow for a targeted surgical approach. The aim of this study was to test the diagnostic value of preoperative PTH washout after FNA in PHPT patients.<p class="...

Introduction: Functional parathyroid cysts represent an uncommon cause of primary hyperparathyroidism (PHPT) and an even rarer cause of a cervical mass.Case report: A 57-year-old woman was referred to our department following emergency treatment of hypercalcaemic crisis (serum calcium 16.4 mg/dl) with i.v. hydration and zoledronic acid. She was found to have multiple vertebral fractures by plain radiographs one month previously. Despite being diagnosed a...

Introduction: Although the association between thyroid autoimmunity and papillary thyroid carcinoma (PTC) is supported by clinical studies, evidence to their pathophysiologic link and causal relationship is lacking. Moreover, there is a paucity of data regarding the association of thyroid autoimmunity with the less common types of differentiated thyroid cancer (DTC). The aim of the current paper was to investigate the association of autoimmunity and PTC vs follicular or medull...

Introduction: Graves’ ophthalmopathy (GO) is common in the course of Graves’ disease, but optic neuropathy is present in only ~5% of patients with GO. We present a case of recalcitrant Graves’ orbitopathy with late development of neuropathy, satisfactorily treated with rituximab.Case report: A 50-year-old female smoker was referred to our department for further management of Graves’ disease with associated GO. She complained of worsen...

Objective: Whereas parathyroidectomy (PTx) has an established benefit in patients with symptomatic primary hyperparathyroidism (PHPT), its efficacy in patients with mild (asymptomatic) PHPT has not been proven. The aim of this study was to systematically investigate and meta-analyze the best available evidence from randomized-controlled trials regarding the efficacy of PTx on fracture risk (primary endpoint), as well as bone mineral density (BMD), serum calcium concentrations,...

Background/Aims: Post-operative hypoparathyroidism still remains a significant complication after thyroidectomy. Intraoperative imaging modalities, such as near infrared fluorescence by the use of indocyanine green (ICG), may assist to identify and preserve the parathyroid glands (PGs). The purpose of this study was to test the association between intra-operative ICG staining scoring system and 24-h post-operative parathyroid hormone (PTH) levels, as well as its capability of ...

Objective: Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). The purpose of this study was to systematically investigate and meta–analyze the best available evidence from randomized–controlled trials (RCTs) regarding the efficacy and safety of statins in children and adolescents with FH.Methods: A comprehensive search was conducted in PubMed, Scopus and Cochrane, up to July 10, 2019. Data were expres...

Introduction: Despite the coexistence of secondary hyperparathyroidism with anaemia, hematological manifestations of primary hyperparathyroidism (PHPT) are rare.Case report: A 67-year-old Caucasian female was admitted to the Department of Internal Medicine due to normocytic anemia and hypercalcemia, diagnosed on occasion of muscle weakness and fatigability for 3 months.Her medication included: alendronate 70 mg/week, alphacalcidol ...

Introduction: The possibility of progression of subclinical hyperthyroidism (SH) to overt hyperthyroidism (OH) is a critical point in deciding whether to treat this situation.The aim of this study is to evaluate the rate of progression of SH to OH and the factors influencing this outcome.Methods/design: This is a retrospective study at an endocrine referral service in Northern Greece. Data from patients with SH diagnosed between 19...